ايرادات مطالعه :
١. افراد مسن كه بيشترين ريسك را دارند از مطالعه كنار گذاشته شده اند .
the population included young military personnel. Soldiers are likely to be fitter and healthier than the general population. Moreover, in older adults, immune senescence might make vaccines less immunogenic, and this age group was absent from this study.
٢. توازن زن و مرد در اين مطالعه رعايت نشده است :
Sex imbalance occurred in the study arms because there was no random allocation. A control arm was conspicuously absent.
٣. اين مطالعات بيشتر بر روي تشكيل آنتي بادي متمركز بوده كه اين يك خطای راهبردي است
Licensure in most settings should depend on proven short-term and long-term efficacy against disease (not just immunogenicity) and more complete safety data, including rates of vaccine failure to prevent infection (not merely disease) and rates of occurrence of antibody-dependent enhanced disease, ideally from very large scale,
٤. تشكيل صرف آنتي بادي مي تواند فريب دهنده باشد .
A vaccine that reduces disease but does not prevent infection might paradoxically make things worse. It could falsely reassure recipients of personal invulnerability, thus reducing transmission- mitigating behaviours. In turn, this could lead to increased exposure among older adults in whom efficacy is likely to be lower, or among other higher-risk groups who might have lower vaccine acceptance and uptake
@Mmt_iran
١. افراد مسن كه بيشترين ريسك را دارند از مطالعه كنار گذاشته شده اند .
the population included young military personnel. Soldiers are likely to be fitter and healthier than the general population. Moreover, in older adults, immune senescence might make vaccines less immunogenic, and this age group was absent from this study.
٢. توازن زن و مرد در اين مطالعه رعايت نشده است :
Sex imbalance occurred in the study arms because there was no random allocation. A control arm was conspicuously absent.
٣. اين مطالعات بيشتر بر روي تشكيل آنتي بادي متمركز بوده كه اين يك خطای راهبردي است
Licensure in most settings should depend on proven short-term and long-term efficacy against disease (not just immunogenicity) and more complete safety data, including rates of vaccine failure to prevent infection (not merely disease) and rates of occurrence of antibody-dependent enhanced disease, ideally from very large scale,
٤. تشكيل صرف آنتي بادي مي تواند فريب دهنده باشد .
A vaccine that reduces disease but does not prevent infection might paradoxically make things worse. It could falsely reassure recipients of personal invulnerability, thus reducing transmission- mitigating behaviours. In turn, this could lead to increased exposure among older adults in whom efficacy is likely to be lower, or among other higher-risk groups who might have lower vaccine acceptance and uptake
@Mmt_iran
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