Enumerate :
- Function of Tropomyosin ?
In the resting state, the tropomyosin molecules cover the active sites of the actin strands, preventing attraction between the actin and myosin filaments .
- Function of T-tubular ?
conduct the action potential from the surface of the muscle to the
muscle fibrils inside.
- Factors affecting neuromuscular transmission:
1. Calcium: facilitates but Mg inhibits neuromuscular transmission.
2. Hypoxia: decrease neuromuscular transmission.
3. Hypoglycaemia: decrease neuromuscular transmission.
4. Drugs:
Anti-choline estrases : facilitate neuromuscular transmission.
Curare: bind with Ach receptors blocking them → inhibit transmission.
Succinyl-choline: initial stimulation of neuromuscular transmission then blocking by producing sustained state of depolarization.
Botulinum toxin: inhibit Ach release inhibit transmission.
- Properties of neuromuscular transmission ?
1) Unidirectional: from the nerve to the muscle not the reverse.
2) Delay: of about 0.5 msec. which is the time needed for the release of acetylcholine until the generation of action potential.
3) Easily fatigued: when depletion of the transmitter takes place.
4) Blocked by curare.
5) Mg prevents the release of the transmitter at the MEP→ decrease the neuromuscular transmission.
Complete :
- Muscle contraction occurs by ...... sliding myosin over actin
- The structural unit of the muscle is the............
Muscle cell (fibrer)
- True or false , muscle contraction occurs by sliding myosin over actin
False
Actin over myosin
- Ca-calmodulin complex is a second messanger
- True or false Unidirectional is from muscle to nerve
False➡️from nerve to muscle
- In neuromuscular transmission delay is happened by 0.5msec
- The Easily fatigue is the neuromuscular junction
- Function of Tropomyosin ?
In the resting state, the tropomyosin molecules cover the active sites of the actin strands, preventing attraction between the actin and myosin filaments .
- Function of T-tubular ?
conduct the action potential from the surface of the muscle to the
muscle fibrils inside.
- Factors affecting neuromuscular transmission:
1. Calcium: facilitates but Mg inhibits neuromuscular transmission.
2. Hypoxia: decrease neuromuscular transmission.
3. Hypoglycaemia: decrease neuromuscular transmission.
4. Drugs:
Anti-choline estrases : facilitate neuromuscular transmission.
Curare: bind with Ach receptors blocking them → inhibit transmission.
Succinyl-choline: initial stimulation of neuromuscular transmission then blocking by producing sustained state of depolarization.
Botulinum toxin: inhibit Ach release inhibit transmission.
- Properties of neuromuscular transmission ?
1) Unidirectional: from the nerve to the muscle not the reverse.
2) Delay: of about 0.5 msec. which is the time needed for the release of acetylcholine until the generation of action potential.
3) Easily fatigued: when depletion of the transmitter takes place.
4) Blocked by curare.
5) Mg prevents the release of the transmitter at the MEP→ decrease the neuromuscular transmission.
Complete :
- Muscle contraction occurs by ...... sliding myosin over actin
- The structural unit of the muscle is the............
Muscle cell (fibrer)
- True or false , muscle contraction occurs by sliding myosin over actin
False
Actin over myosin
- Ca-calmodulin complex is a second messanger
- True or false Unidirectional is from muscle to nerve
False➡️from nerve to muscle
- In neuromuscular transmission delay is happened by 0.5msec
- The Easily fatigue is the neuromuscular junction
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