https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128816/
Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication, which are being tested in clinical trials. Moreover, chloroquine has immunomodulatory effects, suppressing the production/release of tumour necrosis factor α and interleukin 6, which mediate the inflammatory complications of several viral diseases. We review the available information on the effects of chloroquine on viral infections, raising the question of whether this old drug may experience a revival in the clinical management of viral diseases such as AIDS and severe acute respiratory syndrome, which afflict mankind in the era of globalisation.
氯喹具有直接的抗病毒作用，抑制了包括黄病毒，逆转录病毒和冠状病毒在内的几种病毒复制的pH依赖性步骤。 研究最好的效果是针对HIV复制的效果，这些效果正在临床试验中进行测试。 此外，氯喹具有免疫调节作用，抑制肿瘤坏死因子α和白介素6的产生/释放，介导几种病毒性疾病的炎症并发症。 我们回顾了有关氯喹对病毒感染的影响的可用信息，提出了一个问题，即这种旧药是否会在全球化时代困扰人类的艾滋病和严重急性呼吸道综合症等病毒性疾病的临床管理中复苏？
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Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication, which are being tested in clinical trials. Moreover, chloroquine has immunomodulatory effects, suppressing the production/release of tumour necrosis factor α and interleukin 6, which mediate the inflammatory complications of several viral diseases. We review the available information on the effects of chloroquine on viral infections, raising the question of whether this old drug may experience a revival in the clinical management of viral diseases such as AIDS and severe acute respiratory syndrome, which afflict mankind in the era of globalisation.
氯喹具有直接的抗病毒作用，抑制了包括黄病毒，逆转录病毒和冠状病毒在内的几种病毒复制的pH依赖性步骤。 研究最好的效果是针对HIV复制的效果，这些效果正在临床试验中进行测试。 此外，氯喹具有免疫调节作用，抑制肿瘤坏死因子α和白介素6的产生/释放，介导几种病毒性疾病的炎症并发症。 我们回顾了有关氯喹对病毒感染的影响的可用信息，提出了一个问题，即这种旧药是否会在全球化时代困扰人类的艾滋病和严重急性呼吸道综合症等病毒性疾病的临床管理中复苏？
Before Next
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