Our findings provide evidence of the spike protein hijacking the DNA damage repair machinery and adaptive immune machinery in vitro. We propose a potential mechanism by which spike proteins may impair adaptive immunity by inhibiting DNA damage repair. Although no evidence has been published that SARS–CoV–2 can infect thymocytes or bone marrow lymphoid cells, our in vitro V(D)J reporter assay shows that the spike protein intensely impeded V(D)J recombination. Consistent with our results, clinical observations also show that the risk of severe illness or death with COVID–19 increases with age, especially older adults who are at the highest risk [22]. This may be because SARS–CoV–2 spike proteins can weaken the DNA repair system of older people and consequently impede V(D)J recombination and adaptive immunity. In contrast, our data provide valuable details on the involvement of spike protein subunits in DNA damage repair, indicating that full–length spike–based vaccines may inhibit the recombination of V(D)J in B cells, which is also consistent with a recent study that a full–length spike–based vaccine induced lower antibody titers compared to the RBD–based vaccine [28]. This suggests that the use of antigenic epitopes of the spike as a SARS–CoV–2 vaccine might be safer and more efficacious than the full–length spike. Taken together, we identified one of the potentially important mechanisms of SARS–CoV–2 suppression of the host adaptive immune machinery. Furthermore, our findings also imply a potential side effect of the full–length spike–based vaccine. This work will improve the understanding of COVID–19 pathogenesis and provide new strategies for designing more efficient and safer vaccines.“
The two mRNA vaccines in current widespread application (BioNTech-Pfizer and Moderna) (Table 1) are technologically very similar. They contain codon-optimized sequences for efficient expression of the full-length S protein and use the authentic signal sequence for its biosynthesis44,45,46,47 (Fig. 1b).“
There are unfortunately a few unlucky ones who suffer from neurological disorders as post vaccination side effects which are same as in long hauler covid syndrome. I just find it deeply saddening and inhuman that these people beed to hide and cannot speak up openly about their issues as opposed to the radical pro-vaccine campaigners who simply ignore the fact that there might be people out there who had a different experience. We see this in times where laboratories offer generic tests like myPgX to make a personalized profile in order to find out which medication works best and in which dose yet we believe that one vaccine will work same for all individuals.
I am such a case. (33 years old) Although I was extremely negative about the vaccination, I finally let myself be persuaded, mainly by my parents. The problems began a week after the first (and last) Pfizer vaccination on May 7th, 2021 and then peaked after a few weeks. I got excruciating pain at different times, which occurred more and more often. Especially a little to the left behind the breastbone, but also at times in other places. (Head, neck, arms, stomach pain, sometimes extra heart beats, etc.) For months I thought I was going to die, I could hardly think clearly. I was treated with a variety of pain relievers, but they had almost no effect. Then after 4 months of torture they tried "Lyrica", also a Pfizer product, that helps against nerve pain. I now have a lot less pain, but I am nowhere near as good as before the vaccination. Pain is still there, but less. The uncertainty remains whether it will stay that way or whether it will eventually improve. But you can't say that, say the doctors, because you still know very little about the vaccination. It's really bad because I was very fit before the vaccination. (I translated it from german)
For some reason Youtube started recommending your videos to me. (I was never subscribed) In general corporate recommendations have almost vanished for me. Maybe they noticed I now watch as much on Odysee as on YouTube and they want to win me back.
Can someone pls. put the Kyle Rittenhouse video into perspective? There is no comment section there so forgive me my hijacking here.
I understood what was said there but I do not fully grasp the legal implication of the answer "correct". I am lacking context. Who was that witness in the booth in the first place?
Our findings provide evidence of the spike protein hijacking the DNA damage repair machinery and adaptive immune machinery in vitro. We propose a potential mechanism by which spike proteins may impair adaptive immunity by inhibiting DNA damage repair. Although no evidence has been published that SARS–CoV–2 can infect thymocytes or bone marrow lymphoid cells, our in vitro V(D)J reporter assay shows that the spike protein intensely impeded V(D)J recombination. Consistent with our results, clinical observations also show that the risk of severe illness or death with COVID–19 increases with age, especially older adults who are at the highest risk [22]. This may be because SARS–CoV–2 spike proteins can weaken the DNA repair system of older people and consequently impede V(D)J recombination and adaptive immunity. In contrast, our data provide valuable details on the involvement of spike protein subunits in DNA damage repair, indicating that full–length spike–based vaccines may inhibit the recombination of V(D)J in B cells, which is also consistent with a recent study that a full–length spike–based vaccine induced lower antibody titers compared to the RBD–based vaccine [28]. This suggests that the use of antigenic epitopes of the spike as a SARS–CoV–2 vaccine might be safer and more efficacious than the full–length spike. Taken together, we identified one of the potentially important mechanisms of SARS–CoV–2 suppression of the host adaptive immune machinery. Furthermore, our findings also imply a potential side effect of the full–length spike–based vaccine. This work will improve the understanding of COVID–19 pathogenesis and provide new strategies for designing more efficient and safer vaccines.“
https://www.mdpi.com/1999-4915/13/10/2056/htm?fbclid=IwAR1v4nPhnmfVAtaYSWGiiW3LQ-FGUjY1PQBsIq5jw-JZJq-23VWAeowTRS8
The two mRNA vaccines in current widespread application (BioNTech-Pfizer and Moderna) (Table 1) are technologically very similar. They contain codon-optimized sequences for efficient expression of the full-length S protein and use the authentic signal sequence for its biosynthesis44,45,46,47 (Fig. 1b).“
https://www.nature.com/articles/s41541-021-00369-6
I just find it deeply saddening and inhuman that these people beed to hide and cannot speak up openly about their issues as opposed to the radical pro-vaccine campaigners who simply ignore the fact that there might be people out there who had a different experience.
We see this in times where laboratories offer generic tests like myPgX to make a personalized profile in order to find out which medication works best and in which dose yet we believe that one vaccine will work same for all individuals.
Researchers blows the whistle on data integrity issues in Pfizer's vaccine trial.
https://www.bmj.com/content/375/bmj.n2635
I got excruciating pain at different times, which occurred more and more often. Especially a little to the left behind the breastbone, but also at times in other places.
(Head, neck, arms, stomach pain, sometimes extra heart beats, etc.)
For months I thought I was going to die, I could hardly think clearly. I was treated with a variety of pain relievers, but they had almost no effect.
Then after 4 months of torture they tried "Lyrica", also a Pfizer product, that helps against nerve pain. I now have a lot less pain, but I am nowhere near as good as before the vaccination.
Pain is still there, but less.
The uncertainty remains whether it will stay that way or whether it will eventually improve. But you can't say that, say the doctors, because you still know very little about the vaccination.
It's really bad because I was very fit before the vaccination.
(I translated it from german)
I understood what was said there but I do not fully grasp the legal implication of the answer "correct". I am lacking context. Who was that witness in the booth in the first place?